基本信息

李芬芬 特任副研究员 硕士生导师

中国科学技术大学 医学影像中心

研究方向：分子影像、药物递送、转化医学

邮箱：lifenfen@ustc.edu.cn

地址：中国科学技术大学（中校区）医学楼103室

个人主页：https://faculty.ustc.edu.cn/lifenfen

医学影像中心主页：https://bmec.ustc.edu.cn/main.htm

个人简介

开发智能靶向纳米药物/探针以实现药物在肿瘤、炎症、感染等病变部位的高效递送，运用影像学技术进行疾病诊断、药物示踪、治疗指导和疗效监测，并致力于新型生物医用材料的临床转化研究。目前已发表论文30余篇，其中以第一/通讯作者在Cell Biomaterials、Biomaterials、Journal of Materials Science & Technology、Chemical Engineering Journal、Acta Biomaterialia等期刊发表论文14篇，获已授权专利4项。担任安徽省癌症研究会理事，View期刊青年编委，Advanced Science、Advanced Functional Materials、ACS Nano等期刊审稿人。主持国家自然科学基金青年项目、博士后面上项目及省级自然科学基金青年项目，参与国家重大/重点研发计划3项；合作培养博士研究生9名（已毕业5名，在读4名），培养在读硕士研究生3名。

科研项目

[1]2018-01至2020-12，国家自然科学基金委员会，青年项目，主持。

[2]2018-07至2020-06，安徽省自然科学基金委员会，青年项目，主持。

[3]2018-01至2019-12，中国博士后科学基金会，面上项目，主持。

[4]2025-01至2029-12，国家自然科学基金委员会，重大科研仪器研制项目，参加。

[5]2022-12至2027-11，科学技术部，国家重点研发计划青年科学家项目，参与。

[6]2019-01至2021-12，国家自然科学基金委员会，重大研究计划培育项目，参加。

期刊论文

1. F.F. Li#, R. Zhao#, W.P. Ding, J.Y. Yang, Q.Q. Wen, W.Q. Dou, L. Chen, J. Zhang*, B.S. Qiu*, J.W.M. Bulte, Y. Yuan*, Chemical exchange saturation transfer MRI-trackable peptide hydrogel for drug release monitoring and targeted therapy in inflammatory bowel disease, Cell Biomaterials (2025) 100098.

2. S.Z. Wang, C. Yang, Y.Y. Zhang, Y. Hu, L. Xiao, W.P. Ding*, B.S. Qiu*, F.F. Li*, Co-encapsulated Ce6+CpG and biopeptide-modified liposomes for enhanced transdermal photo-immunotherapy of superficial tumors, Materials Today Bio 32 (2025) 101669.

3. M. I. Khan^#,*, R. H. Zhao^#, F. Batool, A. R. Khan, R. Ali, Y. Hu, J. Tian, N. Chen, B.S. Qiu* and F. F. Li*. Folic acid and ferritin functionalized reduced Iron-based metal-organic frameworks for anticancer therapy. International Journal of Biological Macromolecules (2024)137079.

4. H. X. Wang, W. S. Wang, C. P. Li, A. Xu, B. S. Qiu*, F. F. Li* and W. P. Ding*, Flav7+DOX co-loaded separable microneedle for light-triggered chemo-thermal therapy of superficial tumors, Chemical Engineering Journal 428, (2022) 131913.

5. M. I. Khan, F. Batool, R. Ali, Q. U. Zahra, W. S. Wang, S. B. Li, G. G. Wang, L. L. Liu, S. U. Khan, M. Mansoor, M. Bilal, W. P. Ding, A. Kazmi, F. F. Li* and B. S. Qiu*. Tailoring radiotherapies and nanotechnology for targeted treatment of solid tumors. Coordination Chemistry Reviews 472 (2022) 214757.

6. S. U. Khan, M. U. Khan, M. I. Khan*, A. A. Fadahunsi, A. Khan, S. Gao, M. Bilal* and F. F. Li*, Role of circular RNAs in disease progression and diagnosis of cancers: An overview of recent advanced insights. International Journal of Biological Macromolecules 220 (2022) 973-984.

7. Y. Y. Zhang, F. F. Li*, S. N. Ya, Y. Hu, D. B. Zhi, W. S. Wang, M. R. Xu, B. S. Qiu* and W. P. Ding*, An iron oxide nanoparticle-based transdermal nanoplatform for dual-modal imaging-guided chemo-photothermal therapy of superficial tumors, Acta Biomaterialia130 (2021) 473-484.

8. W. S. Wang, F. F. Li*, S. B. Li, Y. Hu, M. R. Xu, Y. Y. Zhang, M. I. Khan, S. Z. Wang, M. Wu, W. P. Ding* and B. S. Qiu*, M2 macrophage-targeted iron oxide nanoparticles for magnetic resonance image-guided magnetic hyperthermia therapy, Journal of Materials Science & Technology 81 (2021) 77-87.

9. F. F. Li^#, T. W. Li^#, D. B. Zhi^#, P. P. Xu, W. S. Wang, Yi. Hu, Y. Y. Zhang, S. Z. Wang, J. Matula Thomas, J. Beauchamp Norman, W. P. Ding*, L. F. Yan* and B. S. Qiu*, Novel ultrasmall multifunctional nanodots for dual-modal MR/NIR-II imaging-guided photothermal therapy, Biomaterials 256 (2020) 120219.

10. M. R. Xu, Y. Hu, Y. Xiao, Y. Y. Zhang, K. L. Sun, T. Wu, N. Lv, W. S. Wang, W. P. Ding,F. F. Li*, B. S. Qiu* and J. B. Li*, Near-Infrared-Controlled Nanoplatform Exploiting Photothermal Promotion of Peroxidase-like and OXD-like Activities for Potent Antibacterial and Anti-biofilm Therapies, ACS Applied Materials & Interfaces 12(45) (2020) 50260-50274.

11. F. F. Li, D. B. Zhi, Y. F. Luo, J. Q. Zhang, X. Nan, Y. J. Zhang, W. Zhou, B. S. Qiu*, L. P. Wen* and G. L. Liang*, Core/shell Fe₃O₄/Gd₂O₃ nanocubes as T₁-T₂ dual modal MRI contrast agents, Nanoscale 8(25) (2016) 12826-12833.

12. X. L. Huang, M. I. Khan*, J. Wang, R. Ali, S. W. Ali, Q. U. Zahra, A. Kazmi, A. Lolai, Y. L. Huang, A. Hussain, M. Bilal, F. F. Li* and B. S. Qiu*, Role of receptor tyrosine kinases mediated signal transduction pathways in tumor growth and angiogenesis-New insight and futuristic vision, International Journal of Biological Macromolecules 180 (2021) 739-752.

13. S. W. Ali, F. A. Mangrio, F. F. Li*, P. Dwivedi, M. U. Rajput, R. Ali, M. I. Khan, W. P. Ding* and R. X. Xu*, Co-delivery of artemether and piperine via core-shell microparticles for enhanced sustained release, Journal of Drug Delivery Science and Technology63 (2021).

14. M. I. Khan, S. R. Xu, M. M. Ali, R. Ali, A. Kazmi, N. Akhtar, M. Bilal, Y. Hu and F. F. Li*, Assessment of multidrug resistance in bacterial isolates from urinary tract-infected patients, Journal of Radiation Research and Applied Sciences13(1) (2020) 267-275.

专利申请

（1）李芬芬、袁月、赵荣华、邱本胜，一种荷载抗炎药的凝胶因子、水凝胶及制备方法和应用，中国，ZL 202311524815.5

（2）李芬芬、汪绍珍、邱本胜、丁卫平，一种透皮肽修饰、含有Ce6和CpG的脂质体及应用，中国，ZL202310412277.4

（3）智德波、李芬芬、邱本胜，一种激光间质热疗装置，中国，ZL 2024100339508

（4）沈梦泽、杨志平、石发展、李芬芬、王鹏飞、孔熙、谢天宇、邱本胜、杜江峰，光超极化核磁共振成像装置及方法，中国，ZL 202011643569.1